As reações de crotonaldeído (8) com tiofenol (2) e benzalacetona (10) com 1,2-etanoditiol (11) levam aos produtos de adição de Michael. As reações de tiofenol (2) com (R)-carvona (13) e (S)-perilaldeído (15) levam aos produtos (2S,3R,5S)-5-isopropenil-2-metil-3-feniltio-cicloexanona (14) e (1R,2R,4S)-4-isopropenil-2-feniltio-cicloexano carbaldeído (16), respectivamente. Também é apresentada a elucidação inequívoca da estereoquímica de 14 e 16 por RMN.

The reactions of crotonaldehyde (8) with thiophenol (2) and benzalacetone (10) with ethane-1,2-dithiol (11) yield Michael addition products. The reactions of thiophenol (2) with (R)-carvone (13) and (S)-perillaldehyde (15) lead to (2S,3R,5S)-5-isopropenyl-2-methyl-3-(phenylthio)cyclohexanone (14) and (1R,2R,4S)-4-isopropenyl-2-(phenylthio)cyclohexanecarbaldehyde (16), respectively. An unambiguous elucidation of the stereochemistry of 14 and 16 by NMR is also presented.

The world is in a process of awakening with respect to the environment. Our society has started to recognize that the environment is one of our largest resources and has begun legally enforce its protection. In Brazil, the environmental law is constitutionally guaranteed. International treaties have been signed, amongst them the Agenda 21 which is a commitment to sustainable development. Green Chemistry is a strategy that helps make this commitment. The literature presents many examples of studies of the application of Green Chemistry philosophy. In this paper we will present some points that we believe to be important and promising.